Abstract
Introduction: A few studies involved the relationship between vitamin D and diabetes mellitus (DM) with erectile dysfunction (ED), and no meta-analysis was conducted to pool these data. The main purpose of our study was to examine the changes in serum vitamin D levels in patients with DM combined with ED. Methods: An extensive search was performed, including the following words: “erectile dysfunction,” “diabetes,” and “vitamin D.” Databases, including Cochrane Library, PubMed, and Web of Science, were retrieved to identify studies published up to September 30, 2021. Four studies were eligible for our meta-analysis. Results: The weighted mean difference and their corresponding 95% confidence intervals were calculated to the data we selected. The results showed that the level of vitamin D in DM with ED was significantly lower (12.5 nmol/mL) than patients with diabetes alone (p = 0.002). Conclusion: Our novel meta-analysis suggests that vitamin D may be a risk factor for DM with ED, which can provide a new idea for the treatment and prevention of DM with ED.
References
1.
Selvin
E
, Burnett
AL
, Platz
EA
. Prevalence and risk factors for erectile dysfunction in the US
. Am J Med
. 2007
;120
(2
):151
–7
. .2.
Shamloul
R
, Ghanem
H
. Erectile dysfunction
. Lancet
. 2013
;381
(9861
):153
–65
. .3.
Malavige
LS
, Levy
JC
. Erectile dysfunction in diabetes mellitus
. J Sex Med
. 2009
;6
(5
):1232
–47
. .4.
Feldman
HA
, Goldstein
I
, Hatzichristou
DG
, Krane
RJ
, McKinlay
JB
. Impotence and its medical and psychosocial correlates: results of the Massachusetts male aging study
. J Urol
. 1994
;151
(1
):54
–61
. .5.
Virag
R
, Bouilly
P
, Frydman
D
. Is impotence an arterial disorder? A study of arterial risk factors in 440 impotent men
. Lancet
. 1985
;1
(8422
):181
–4
. .6.
Sullivan
ME
, Thompson
CS
, Dashwood
MR
, Khan
MA
, Jeremy
JY
, Morgan
RJ
, Nitric oxide and penile erection: is erectile dysfunction another manifestation of vascular disease?
Cardiovasc Res
. 1999
;43
(3
):658
–65
.7.
Vlachopoulos
C
, Rokkas
K
, Ioakeimidis
N
, Stefanadis
C
. Inflammation, metabolic syndrome, erectile dysfunction, and coronary artery disease: common links
. Eur Urol
. 2007
;52
(6
):1590
–600
. .8.
Shah
NP
, Cainzos-Achirica
M
, Feldman
DI
, Blumenthal
RS
, Nasir
K
, Miner
MM
, Cardiovascular disease prevention in men with vascular erectile dysfunction: the view of the preventive cardiologist
. Am J Med
. 2016
;129
(3
):251
–9
.9.
Kutner
A
, Brown
G
. Vitamins D: relationship between structure and biological activity
. Int J Mol Sci
. 2018
;19
(7
):2119
. .10.
McCollum
EV
, Pitz
W
, Simmonds
N
, Becker
JE
, Shipley
PG
, Bunting
RW
. The effect of additions of fluorine to the diet of the rat on the quality of the teeth. 1925. Studies on experimental rickets. XXI. An experimental demonstration of the existence of a vitamin which promotes calcium deposition. 1922. The effect of additions of fluorine to the diet of the rat on the quality of the teeth. 1925
. J Biol Chem
. 2002
;277
(19
):E8
.11.
Lips
P
. Relative value of 25(OH)D and 1,25(OH)2D measurements
. J Bone Miner Res
. 2007
;22
(11
):1668
–71
. .12.
Farag
YMK
, Guallar
E
, Zhao
D
, Kalyani
RR
, Blaha
MJ
, Feldman
DI
, Vitamin D deficiency is independently associated with greater prevalence of erectile dysfunction: the national health and nutrition examination survey (NHANES) 2001–2004
. Atherosclerosis
. 2016
;252
:61
–7
.13.
Tarcin
O
, Yavuz
DG
, Ozben
B
, Telli
A
, Ogunc
AV
, Yuksel
M
, Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects
. J Clin Endocrinol Metab
. 2009
;94
(10
):4023
–30
.14.
Grant
WB
, Sorenson
M
, Boucher
BJ
. Vitamin D deficiency may contribute to the explanation of the link between chronic periodontitis and erectile dysfunction
. J Sex Med
. 2013
;10
(9
):2353
–4
. .15.
Barassi
A
, Pezzilli
R
, Colpi
GM
, Corsi Romanelli
MM
, Melzi d’Eril
GV
. Vitamin D and erectile dysfunction
. J Sex Med
. 2014
;11
(11
):2792
–800
. .16.
Song
Y
, Wang
L
, Pittas
AG
, Del Gobbo
LC
, Zhang
C
, Manson
JE
, Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies
. Diabetes Care
. 2013
;36
(5
):1422
–8
.17.
Al-Timimi
DJ
, Ali
AF
. Serum 25(OH) D in diabetes mellitus type 2: relation to glycaemic control
. J Clin Diagn Res
. 2013
;7
(12
):2686
–8
. .18.
Moher
D
, Liberati
A
, Tetzlaff
J
, Altman
DG
. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
. BMJ
. 2009
;339
:b2535
. .19.
Higgins
JP
, Thompson
SG
, Deeks
JJ
, Altman
DG
. Measuring inconsistency in meta-analyses
. BMJ
. 2003
;327
(7414
):557
–60
. .20.
DerSimonian
R
, Laird
N
. Meta-analysis in clinical trials
. Control Clin Trials
. 1986
;7
(3
):177
–88
. .21.
Caretta
N
, de Kreutzenberg
SV
, Valente
U
, Guarneri
G
, Ferlin
A
, Avogaro
A
, Hypovitaminosis D is associated with erectile dysfunction in type 2 diabetes
. Endocrine
. 2016 Sep
;53
(3
):831
–8
.22.
Basat
S
, Sivritepe
R
, Ortaboz
D
, Sevim Çalık
E
, Küçük
EV
, Şimşek
B
, The relationship between vitamin D level and erectile dysfunction in patients with type 2 diabetes mellitus
. Aging Male
. 2018 Jun
;21
(2
):111
–5
.23.
Arıman
A
, Merder
E
, Çulha
MG
, Ermeç
B
, Karakanlı
MU
, Adaş
M
. Relation of glycated hemoglobin and vitamin D deficiency with erectile dysfunction in patients with type 2 diabetes mellitus
. Andrologia
. 2021 Apr 27
;53
(7
):e14076
. .24.
Boucher
BJ
, John
WG
, Noonan
K
. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction
. Am J Clin Nutr
. 2004
;80
(6
):1666
. .25.
Scragg
R
, Sowers
M
, Bell
C
. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third national health and nutrition examination survey
. Diabetes Care
. 2004
;27
(12
):2813
–8
. .26.
Reis
JP
, von Mühlen
D
, Michos
ED
, Miller
ER
, Appel
LJ
, Araneta
MR
, Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosis
. Atherosclerosis
. 2009
;207
(2
):585
–90
.27.
Billups
KL
, Bank
AJ
, Padma-Nathan
H
, Katz
SD
, Williams
RA
. Erectile dysfunction as a harbinger for increased cardiometabolic risk
. Int J Impot Res
. 2008
;20
(3
):236
–42
. .28.
Solomon
H
, Man
JW
, Jackson
G
. Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator
. Heart
. 2003
;89
(3
):251
–3
. .29.
Bird
IM
. Endothelial nitric oxide synthase activation and nitric oxide function: new light through old windows
. J Endocrinol
. 2011 Sep
;210
(3
):239
–41
. .30.
Polidoro
L
, Properzi
G
, Marampon
F
, Gravina
GL
, Festuccia
C
, Di Cesare
E
, Vitamin D protects human endothelial cells from HO oxidant injury through the Mek/Erk-Sirt1 axis activation
. J Cardiovasc Transl Res
. 2013
;6
(2
):221
–31
.31.
Andrukhova
O
, Slavic
S
, Zeitz
U
, Riesen
SC
, Heppelmann
MS
, Ambrisko
TD
, Vitamin D is a regulator of endothelial nitric oxide synthase and arterial stiffness in mice
. Mol Endocrinol
. 2014
;28
(1
):53
–64
.32.
Talib
RA
, Khalafalla
K
, Cangüven
Ö
. The role of vitamin D supplementation on erectile function
. Turk J Urol
. 2017
;43
(2
):105
–11
. .33.
Wong
MS
, Delansorne
R
, Man
RY
, Svenningsen
P
, Vanhoutte
PM
. Chronic treatment with vitamin D lowers arterial blood pressure and reduces endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat
. Am J Physiol Heart Circ Physiol
. 2010
;299
(4
):H1226
–34
. .34.
Hirata
M
, Serizawa
KI
, Aizawa
K
, Yogo
K
, Tashiro
Y
, Takeda
S
, 22-Oxacalcitriol prevents progression of endothelial dysfunction through antioxidative effects in rats with type 2 diabetes and early-stage nephropathy
. Nephrol Dial Transplant
. 2013
;28
(5
):1166
–74
.35.
Sorenson
M
, Grant
WB
. Does vitamin D deficiency contribute to erectile dysfunction?
Dermatoendocrinol
. 2012
;4
(2
):128
–36
. .36.
Cantorna
MT
, Zhu
Y
, Froicu
M
, Wittke
A
. Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system
. Am J Clin Nutr
. 2004
;80
(6 Suppl l
):1717S
–20S
. .37.
Hirani
V
. Relationship between vitamin D and hyperglycemia in older people from a nationally representative population survey
. J Am Geriatr Soc
. 2011
;59
(10
):1786
–92
. .38.
Mirhosseini
N
, Rainsbury
J
, Kimball
SM
. Vitamin D Supplementation, Serum 25(OH)D concentrations and cardiovascular disease risk factors: a systematic review and meta-analysis
. Front Cardiovasc Med
. 2018
;5
:87
. .39.
Manson
JE
, Cook
NR
, Lee
IM
, Christen
W
, Bassuk
SS
, Mora
S
, Vitamin D supplements and prevention of cancer and cardiovascular disease
. N Engl J Med
. 2019
;380
(1
):33
–44
.40.
Canguven
O
, Talib
RA
, El Ansari
W
, Yassin
DJ
, Al Naimi
A
. Vitamin D treatment improves levels of sexual hormones, metabolic parameters and erectile function in middle-aged vitamin D deficient men
. Aging Male
. 2017 Mar
;20
(1
):9
–16
. .41.
Chen
L
, Staubli
SEL
, Schneider
MP
, Kessels
AG
, Ivic
S
, Bachmann
LM
, Phosphodiesterase 5 inhibitors for the treatment of erectile dysfunction: a trade-off network meta-analysis
. Eur Urol
. 2015
;68
(4
):674
–80
.42.
Gong
B
, Ma
M
, Xie
W
, Yang
X
, Huang
Y
, Sun
T
, Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis
. Int Urol Nephrol
. 2017
;49
(10
):1731
–40
.43.
Man
L
, Li
G
. Low-intensity extracorporeal shock wave therapy for erectile dysfunction: a systematic review and meta-analysis
. Urology
. 2018
;119
:97
. .44.
Raharinavalona
SA
, Chevalier
N
, Gruel
C
, N’Toutoum
AC
, Vélayoudom Céphise
FL
. What is the best biological parameter to predict erectile dysfunction in men aged >55 years with type 2 diabetes?
J Diabetes Investig
. 2020
;11
(1
):170
–73
. https://pubmed.ncbi.nlm.nih.gov/31148390.© 2022 S. Karger AG, Basel
2022
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