Latest in Sleep Research

This article collection collates research and review articles from Karger’s portfolio from recent years. Within this collection, we are highlighting the latest findings about sleep in the context of medical conditions and health.

Sleep-wake Disorders

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  Diagnostic Validity of the Sleep Condition Indicator to Screen for Diagnostic and Statistical Manual-5 Insomnia Disorder in Patients with Parkinson’s Disease
  Bayard S. · Lebrun C. · Arifi-Rossignol A. · Geny C. · Gély-Nargeot M.-C. · Luik A.I.
  Eur Neurol 2021;84:333–339 (DOI:10.1159/000508185)

   

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  Nurse-Guided Internet-Delivered Cognitive Behavioral Therapy for Insomnia in General Practice: Results from a Pragmatic Randomized Clinical Trial
  Van der Zweerde T. · Lancee J. · Slottje P. · Bosmans J.E. · Van Someren E.J.W. · van Straten A.
  Psychother Psychosom 2020;89:174–184 (DOI:10.1159/000505600)

   

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  Treating Insomnia with High Risk of Depression Using Therapist-Guided Digital Cognitive, Behavioral, and Circadian Rhythm Support Interventions to Prevent Worsening of Depressive Symptoms: A Randomized Controlled Trial
  Leerssen J. · Lakbila-Kamal O. · Dekkers L.M.S. · Ikelaar S.L.C. · Albers A.C.W. · Blanken T.F. · Lancee J. · van der Lande G.J.M. · Maksimovic T. · Mastenbroek S.E. · Reesen J.E. · van de Ven S. · van der Zweerde T. · Foster-Dingley J.C. · Van Someren E.J.W.
  Psychother Psychosom 2022;91:168–179 (DOI:10.1159/000520282)

   

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  A Randomized Clinical Trial of Cognitive-Behavioral Therapy for Insomnia to Augment Posttraumatic Stress Disorder Treatment in Survivors of Interpersonal Violence
  Pigeon W.R. · Crean H.F. · Cerulli C. · Gallegos A.M. · Bishop T.M. · Heffner K.L.
  Psychother Psychosom 2022;91:50–62 (DOI:10.1159/000517862)

   

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  Imagery Rescripting and Imaginal Exposure in Nightmare Disorder Compared to Positive Imagery: A Randomized Controlled Trial
  Schmid C. · Hansen K. · Kröner-Borowik T. · Steil R.
  Psychother Psychosom 2021;90:328–340 (DOI:10.1159/000512757)

   

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  Evaluation of Obstructive Sleep Apnea in Female Patients in Primary Care: Time for Improvement?
  Bouloukaki I. · Tsiligianni I. · Schiza S.
  Med Princ Pract 2021;30:508–514 (DOI:10.1159/000518932)

   

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  Genetic Association Study of Restless Legs Syndrome in Chinese Population
  Chen J. · Luo Q. · Li G. · Huang Y. · Ma J.
  Eur Neurol 2019;81:47–55 (DOI:10.1159/000500416)

   

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  Phantom Restless Legs Syndrome
  Raggi A. · Ferri R.
  Eur Neurol 2019;81:302–308 (DOI:10.1159/000503103)

   

Sleep Behavior Disorder

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  A Questionnaire-Based Study on Clinical REM Sleep Behavior Disorder and Subtypes in Multiple System Atrophy
  Wu D. · Su W. · Li S. · He J. · Li K. · Chen H.-B. · Jin Y.
  Eur Neurol 2021;84:368–374 (DOI:10.1159/000517149)

   

Sleep and Mental Disorders

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  Dysregulated Diurnal Cortisol Pattern and Heightened Night-Time Cortisol in Individuals with Bipolar Disorder
  Mukherjee D. · Weissenkampen J.D. · Wasserman E. · Krishnamurthy V.B. · Millett C.E. · Conway S. · Saunders E.F.H.
  Neuropsychobiology 2022;81:51-59 (DOI:10.1159/000517343)

   

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  Dysfunctional Overnight Memory Consolidation in Patients with Schizophrenia in Comparison to Healthy Controls: Disturbed Slow-Wave Sleep as Contributing Factor?
  Weinhold S.L. · Lechinger J. · Ittel J. · Ritzenhoff R. · Drews H.J. · Junghanns K. · Göder R.
  Neuropsychobiology 2022;81:104-115 (DOI:10.1159/000517858)

   

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  The Many Faces of Sleep Disorders in Post-Traumatic Stress Disorder: An Update on Clinical Features and Treatment
  Weber F.C. · Wetter T.C.
  Neuropsychobiology 2022;81:85-97 (DOI:10.1159/000517329)

   

Sleep and Mental Health

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  Targeting Arousal and Sleep through Noninvasive Brain Stimulation to Improve Mental Health
  Geiser T. · Hertenstein E. · Fehér K. · Maier J.G. · Schneider C.L. · Züst M.A. · Wunderlin M. · Mikutta C. · Klöppel S. · Nissen C.
  Neuropsychobiology 2020;79:284-292 (DOI:10.1159/000507372)

   

Dementia and Neurodegeneration

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  Heart Rate Variability during Wake and Sleep in Huntington’s Disease Patients: An Observational, Cross-Sectional, Cohort Study
  Marotta J. · Piano C. · Brunetti V. · Genovese D. · Bentivoglio A.R. · Calabresi P. · Cortelli P. · Della Marca G.
  Neurodegener Dis 2021;21:79-86 (DOI:10.1159/000520754)

   

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  Natural Age-Related Slow-Wave Sleep Alterations Onset Prematurely in the Tg2576 Mouse Model of Alzheimer’s Disease
  Kollarik S. · Dias I. · Moreira C.G. · Bimbiryte D. · Miladinovic D. · Buhmann J.M. · Baumann C.R. · Noain D.
  Neurodegener Dis 2022;22:55-67 (DOI:10.1159/000527786)

   

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  Association between White Matter Lesions and Non-Motor Symptoms in Parkinson Disease
  Lee J.-Y. · Kim J.S. · Jang W. · Park J. · Oh E. · Youn J. · Park S. · Cho J.W.
  Neurodegener Dis 2018;18:127-132 (DOI:10.1159/000489311)

   

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  Effects of Sleep-Related Disorders on the Prognosis of Amyotrophic Lateral Sclerosis
  Reyhani A. · Benbir Senel G. · Karadeniz D.
  Neurodegener Dis 2019;19:148-154 (DOI:10.1159/000505575)

   

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  Poor Diet, Stress, and Inactivity Converge to Form a “Perfect Storm” That Drives Alzheimer’s Disease Pathogenesis
  Pacholko A.G. · Wotton C.A. · Bekar L.K.
  Neurodegener Dis 2019;19:60-77 (DOI:10.1159/000503451)

   

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  Long-Term Occupational Sleep Loss and Post-Retirement Cognitive Decline or Dementia
  Thomas J. · Overeem S. · Claassen J.A.H.R.
  Dement Geriatr Cogn Disord 2019;48:105-112 (DOI:10.1159/000504020)

   

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  Sleep Disturbance and the Risk of Cognitive Decline or Clinical Conversion in the ADNI Cohort
  Mecca A.P. · Michalak H.R. · McDonald J.W. · Kemp E.C. · Pugh E.A. · Becker M.L. · Mecca M.C. · van Dyck C.H. · The Alzheimer’s Disease Neuroimaging Initiative (ADNI)
  Dement Geriatr Cogn Disord 2018;45:232-242 (DOI:10.1159/000488671)

   

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  Effects of Light Treatment on Sleep, Cognition, Mood, and Behavior in Alzheimer’s Disease: A Systematic Review
  Mitolo M. · Tonon C. · La Morgia C. · Testa C. · Carelli V. · Lodi R.
  Dement Geriatr Cogn Disord 2018;46:371-384 (DOI:10.1159/000494921)

   

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  New Delirium Severity Indicators: Generation and Internal Validation in the Better Assessment of Illness (BASIL) Study
  Vasunilashorn S.M. · Schulman-Green D. · Tommet D. · Fong T.G. · Hshieh T.T. · Marcantonio E.R. · Metzger E.D. · Schmitt E.M. · Tabloski P.A. · Travison T.G. · Gou Y. · Helfand B. · Inouye S.K. · Jones R.N. · the BASIL Study Team
  Dement Geriatr Cogn Disord 2020;49:77-90 (DOI:10.1159/000506700)

   

Sleep and Gait

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  Examining Relationships between Multiple Self-Reported Sleep Measures and Gait Domains in Cognitively Healthy Older Adults
  Bernstein J.P.K. · De Vito A. · Weitzner D.S. · MacAulay R. · Calamia M. · Brouillette R. · Foil H. · Carmichael O.T. · Keller J.N.
  Gerontology 2020;66:47-54 (DOI:10.1159/000499737)

   

Sleep and Immune Function

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  Chronic Sleep Restriction Impairs the Antitumor Immune Response in Mice
  De Lorenzo B.H.P. · Novaes e Brito R.R. · Paslar Leal T. · Piqueira Garcia N. · Martins dos Santos R.M. · Alvares-Saraiva A.M. · Perez Hurtado E.C. · Braga dos Reis T.C. · Duarte Palma B.
  Neuroimmunomodulation 2018;25:59–67 (DOI:10.1159/000490352)

   

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  Sleep Patterns and Development of Children with Atopic Dermatitis
  Torun E.G. · Ertugrul A. · Tekguc D.C. · Bostanci I.
  Int Arch Allergy Immunol 2020;181:871–878 (DOI:10.1159/000509402)

   

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  Sleep, Immunological Memory, and Inflammatory Skin Disease
  Myers B. · Reddy V. · Chan S. · Thibodeaux Q. · Brownstone N. · Bhutani T.
  Dermatology 2021;237:1035–1038 (DOI:10.1159/000510082)

   

Sleep in Cancer

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  Being a Cancer Patient during the Time of COVID-19: Impact of the Pandemic on the Anxiety and the Sleeping Quality of Oncology Patients
  Güç Z.G. · Alacacıoğlu A. · Yazır M.G. · Kalender M.E. · Ünal S. · Oflazoğlu U. · Yıldız Y. · Salman T. · Küçükzeybek Y. · Ellidokuz H. · Tarhan M.O.
  Chemotherapy 2022;67:29-36 (DOI:10.1159/000520483)

   

Sleep Disturbance as Adverse Reaction to Treatment

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  Why Do Our Cancer Patients Sleep So Badly? Sleep Disorders in Cancer Patients: A Frequent Symptom with Multiple Causes
  Strik H. · Cassel W. · Teepker M. · Schulte T. · Riera-Knorrenschild J. · Koehler U. · Seifart U.
  Oncol Res Treat 2021;44:469-475 (DOI:10.1159/000518108)

   

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  Meta-Analysis of Changes in Sleep Quality of Women with Breast Cancer before and after Therapy
  Chang W.-P. · Chang Y.-P.
  Breast Care 2020;15:227-235 (DOI:10.1159/000502943)

   

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  A Prospective Longitudinal Study about Change of Sleep, Anxiety, Depression, and Quality of Life in Each Step of Breast Cancer Patients
  Kim J.H. · Paik H.-J. · Jung Y.J. · Kim D. · Jo H.J. · Lee S. · Kim H.Y.
  Oncology 2019;97:245-253 (DOI:10.1159/000500724)

   

Sleep and Kidney Disease

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  Association of Sleep Duration with Physical Performance in Hemodialysis Patients: A Multicenter Cross-Sectional Study
  Zhan Q. · Zhao J. · Guo Q. · Niu J. · Yu C. · Ding W. · Zhang L. · Qi H. · Shao X.
  Nephron (DOI:10.1159/000527406)

   

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  The Role of Melatonin in Chronic Kidney Disease and Its Associated Risk Factors: A New Tool in Our Arsenal?
  Theofilis P. · Vordoni A. · Kalaitzidis R.G.
  Am J Nephrol 2022;53:565-574 (DOI:10.1159/000525441)

   

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  Impact of Sleep Duration on Mortality and Quality of Life in Chronic Kidney Disease: Results from the 2007-2015 KNHANES
  Lee H.J. · Kwak N. · Kim Y.C. · Choi S.M. · Lee J. · Park Y.S. · Lee C.-H. · Lee S.-M. · Yoo C.-G. · Cho J.
  Am J Nephrol 2021;52:396-403 (DOI:10.1159/000516096)

   

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  Association between Sleep Duration and Incident Chronic Kidney Disease: A Population-Based Cohort Analysis of the NAGALA Study
  Nakajima H. · Hashimoto Y. · Okamura T. · Obora A. · Kojima T. · Hamaguchi M. · Fukui M.
  Kidney Blood Press Res 2020;45:339-349 (DOI:10.1159/000504545)

   

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  Improved Sleep Quality Improves Blood Pressure Control among Patients with Chronic Kidney Disease: A Pilot Study
  Ali W. · Gao G. · Bakris G.L.
  Am J Nephrol 2020;51:249-253 (DOI:10.1159/000505895)

   

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  Effect of Ultrafiltration on Sleep Apnea and Cardiac Function in End-Stage Renal Disease
  Inami T. · Lyons O.D. · Perger E. · Yadollahi A. · Floras J.S. · Chan C.T. · Bradley T.D.
  Am J Nephrol 2020;51:139-146 (DOI:10.1159/000505445)

   

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  Sleep Disorders and Cognitive Impairment in Peritoneal Dialysis: A Multicenter Prospective Cohort Study
  Zhao Y. · Zhang Y. · Yang Z. · Wang J. · Xiong Z. · Liao J. · Hao L. · Liu G. · Ren Y. · Wang Q. · Duan L. · Zheng Z. · Dong J.
  Kidney Blood Press Res 2019;44:1115-1127 (DOI:10.1159/000502355)

   

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  Effect of Hemodiafiltration on Self-Reported Sleep Duration: Results from a Randomized Controlled Trial
  Han M. · Guedes M. · Larkin J. · Raimann J.G. · Lesqueves Barra A.B. · Canziani M.E.F. · Cuvello Neto A.L. · Poli-de-Figueiredo C.E. · Kotanko P. · Pecoits-Filho R.
  Blood Purif 2020;49:168-177 (DOI:10.1159/000504242)

   

Sleep and Gastrointestinal Diseases

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  Sleep Disturbance and Its Association with Gastrointestinal Symptoms/Diseases and Psychological Comorbidity
  Lei W.-Y. · Chang W.-C. · Wong M.-W · Hung J.-S. · Wen S.-H. · Yi C.-H. · Liu T.-T. · Chen J.-H. · Hsu C.-S. · Hsieh T.-C. · Chen C.-L.
  Digestion 2019;99:205–212 (DOI:10.1159/000490941)

   

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  Sleep Disturbance in Inflammatory Bowel Disease Is Associated with Disease Activity and Adverse Outcome
  Leal T. · Gonçalves M. · Antunes P. · Costa D. · Mendes S. · Soares J.B. · Rebelo A. · Gonçalves B. · Arroja B. · Gonçalves R.
  Dig Dis 2021;39:496–501 (DOI:10.1159/000515218)

   

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  The Effect of Dream Anxiety on Sleep Quality in Inflammatory Bowel Diseases
  Kani H.T. · Sakalli Kani A. · Dural U. · Basgoze E. · Aksu C. · Kahraman M.M. · Ozen Alahdab Y. · Atug O. · Kuscu K. · Imeryuz N.
  Dig Dis 2020;38:380–389 (DOI:10.1159/000504748)

   

Sleep Disorder and Hormones

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  Influence of Sleep Stage on LH Pulse Initiation in the Normal Late Follicular Phase and in Polycystic Ovary Syndrome
  Lu C. · Hutchens E.G. · Farhy L.S. · Bonner H.G. · Suratt P.M. · McCartney C.R.
  Neuroendocrinology 2018;107:60–72 (DOI:10.1159/000488110)

   

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  The Potential Role of Sleep in Promoting a Healthy Body Composition: Underlying Mechanisms Determining Muscle, Fat, and Bone Mass and Their Association with Sleep
  Stich F.M. · Huwiler S. · D’Hulst G. · Lustenberger C.
  Neuroendocrinology 2022;112:673–701 (DOI:10.1159/000518691)

   

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  Morbidity, Mortality, and Conversion to Neurodegenerative Diseases in Patients with REM Sleep Behavior Disorder and REM Sleep without Atonia
  Asah C. · Frandsen R. · Ibsen R. · Kjellberg J. · Jennum P.
  Neuroepidemiology 2021;55:141–153 (DOI:10.1159/000514175)

   

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  Sleep-Disordered Breathing in Children with Prader-Willi Syndrome in Relation to Growth Hormone Therapy Onset
  Zimmermann M. · Laemmer C. · Woelfle J. · Fimmers R. · Gohlke B.
  Horm Res Paediatr 2020;93:85–93 (DOI:10.1159/000506943)

   

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  Obstructive Sleep Apnea and Otolaryngologic Manifestations in Children with Pseudohypoparathyroidism
  Curley K.L. · Kahanda S. · Perez K.M. · Malow B.A. · Shoemaker A.H.
  Horm Res Paediatr 2018;89:178–183 (DOI:10.1159/000486715)

   

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  The Effect of Aromatherapy on Sleep and Quality of Life in Menopausal Women with Sleeping Problems: A Non-Randomized, Placebo-Controlled Trial
  Gürler M. · Kızılırmak A. · Baser M.
  Complement Med Res 2020;27:421–430 (DOI:10.1159/000507751)

   

Sleep and Cardiovascular Diseases

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  Effects of Apnea, Obesity, and Statin Therapy on Proprotein Convertase Subtilisin/Kexin 9 Levels in Patients with Obstructive Sleep Apnea
  Milojević A. · Zdravković M. · Brajković M. · Memon L. · Gardijan V. · Vekić J. · Zeljković A. · Stefanović A. · Mihajlović M. · Ivanišević J. · Bogavac-Stanojević N. · Radosavljević V. · Spasojević-Kalimanovska V. · Ninić A.
  Med Princ Pract 2022;31:293–300 (DOI:10.1159/000524087)

   

Sleep Quality

Measuring Sleep Quality

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  Developing a Novel Measurement of Sleep in Rheumatoid Arthritis: Study Proposal for Approach and Considerations
  Crouthamel M. · Mather R.J. · Ramachandran S. · Bode K. · Chatterjee G. · Garcia-Gancedo L. · Kim J. · Alaj R. · Wipperman M.F. · Leyens L. · Sillen H. · Murphy T. · Benecky M. · Maggio B. · Switzer T.
  Digit Biomark 2021;5:191-205 (DOI:10.1159/000518024)

   

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  Objective Home-Monitoring of Physical Activity, Cardiovascular Parameters, and Sleep in Pediatric Obesity
  Knijff J.M. · Houdijk E.C.A.M. · van der Kaay D.C.M. · van Berkel Y. · Filippini L. · Stuurman F.E. · Cohen A.F. · Driessen G.J.A. · Kruizinga M.D.
  Digit Biomark 2022;6:19-29 (DOI:10.1159/000522185)

   

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  A Pivotal Study to Validate the Performance of a Novel Wearable Sensor and System for Biometric Monitoring in Clinical and Remote Environments
  Sen-Gupta E. · Wright D.E. · Caccese J.W. · Wright Jr. J.A. · Jortberg E. · Bhatkar V. · Ceruolo M. · Ghaffari R. · Clason D.L. · Maynard J.P. · Combs A.H.
  Digit Biomark 2019;3:1-13 (DOI:10.1159/000493642)

   

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  A Thorough Examination of Morning Activity Patterns in Adults with Arthritis and Healthy Controls Using Actigraphy Data
  Keogh A. · Sett N. · Donnelly S. · Mullan R. · Gheta D. · Maher-Donnelly M. · Illiano V. · Calvo F. · Dorn J.F. · Mac Namee B. · Caulfield B.
  Digit Biomark 2020;4:78-88 (DOI:10.1159/000509724)

   

Sleep Quality in Palliative Care

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  The Effect of Lavender Oil on Sleep Quality and Vital Signs in Palliative Care: A Randomized Clinical Trial
  Yıldırım D. · Kocatepe V. · Can G. · Sulu E. · Akış H. · Şahin G. · Aktay E.
  Complement Med Res 2020;27:328-335 (DOI:10.1159/000507319)

   

Sleep and Other Conditions

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  A Longitudinal Study of Bidirectional Relationships between Sleep Disorder and Frequency of Nocturia: Results from the Iwaki Health Promotion Project
  Konishi S. · Hatakeyama S. · Imai A. · Kumagai M. · Okamoto T. · Okita K. · Hamano I. · Narita T. · Kojima Y. · Iwamura H. · Yamamoto H. · Yoneyama T. · Yoneyama T. · Hashimoto Y. · Ohyama C.
  Urol Int 2021;105:232–239 (DOI:10.1159/000509976)

   

Further Resources